Victoria Miro first opened her gallery in Cork Street, Mayfair in 1985. The gallery quickly earned acclaim for showing the work of established and emerging artists from the USA, Europe and Asia, and for nurturing the careers of young artists from the UK. In 2000 Victoria Miro Gallery relocated to a sensitively converted, 8,000-square-foot former furniture factory situated between Hoxton and Islington in northeast London. With exhibition spaces on two floors, the gallery is almost unique in London for having its own garden, a beautiful landscaped area overlooking a restored stretch of the Regent's Canal at Wenlock Basin which has been used to great effect for installations by gallery artists such as Yayoi Kusama.

In October 2006 the gallery expanded further by opening Victoria Miro 14, a 9,000-square-foot exhibition and viewing space open to the public for special exhibitions and projects.